Massive macroglossia, a rare side effect of COVID-19: clinical, histologic, and genomic findings in COVID-19-positive versus COVID-19-negative patientsArticle Published on 2022-12-012022-11-16 Journal: Oral and maxillofacial surgery [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] African analysis CD45 COVID-19 Genetic Genetic predisposition Genetic testing genomic histologic histology Histopathology identify IHC immune cells immune response immunohistochemistry include Inconclusive individual infected with SARS-CoV-2 Intubated massive oral oral pathology oral surgery Oral surgery. organ Patient persistence Result retrospective robust Secondary objective Sequencing Side effect susceptibility tissue samples tissues whole-exome sequencing [DOI] 10.1007/s10006-021-01031-0 PMC 바로가기
Differential transcriptomic landscapes of multiple organs from SARS-CoV-2 early infected rhesus macaquesSARS-CoV-2 초기 감염된 붉은털 원숭이의 여러 기관의 차등 전사체 풍경Article Published on 2022-12-012022-09-11 Journal: Protein & Cell [Category] COVID19(2023년), SARS, 유전자 메커니즘, 진단, [키워드] accompanied analyzed Angiogenesis cause Central nervous system cerebral cortex changes in clinical complications clinical manifestation clinical manifestations CNS Coagulation controls drastic dysregulation early infection elevated Encephalitis evidenced examined exhibited expression expressions Factor fibrosis function Genes hyperinflammatory state immune response immune responses infected with SARS-CoV-2 Infection Inflammation inflammation response Inflammatory factor inflammatory factors mechanism multiple organ neuropilin 1 NRP1 organs positive positive feedback post infection provide receptor rhesus rhesus macaque right ventricle SARS-CoV-2 SARS-COV-2 infection significantly tissue tissues transcriptomic transcriptomic alteration Transmission up-regulated upregulation Viral viral encephalitis viral encephalitis. [DOI] 10.1007/s13238-022-00915-5 PMC 바로가기 [Article Type] Article
Induction of pulmonary HLA-G expression by SARS-CoV-2 infectionArticle Published on 2022-11-052022-11-15 Journal: Cellular and Molecular Life Sciences [Category] SARS, 치료기술, 치료제, [키워드] accompanied Antigen Autopsy biopsies CD8 Cell changes in correlated distribution epithelial cell Evidence expressed expression expression level Frequency heart muscle HLA-G Hyperactivation Immune cell Immune cell infiltration immune cells Immune escape immune response induction information kidney leukocyte lung lung alveolar lung epithelia lung epithelial cell lung tissue Macrophage marker microRNA microRNA. miRNA miRNA expression modulating organs other organ patients protein expression SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 infections SARS-CoV-2 nucleocapsid SARS-CoV-2- SARS-CoV-2-infected patient specimen Spike protein surgical T cell responses T cells therapeutic target tissue tissues Treatment Tumor virus-infected cells while [DOI] 10.1007/s00018-022-04592-9 PMC 바로가기
CASA: a comprehensive database resource for the COVID-19 Alternative Splicing AtlasArticle Published on 2022-10-202022-11-15 Journal: Journal of Translational Medicine [Category] 유전자 메커니즘, 치료기술, 치료제, [키워드] affected alteration Analysis Atla cell line conditions COVID-19 database dataset Diseases drug-target interaction event events facilitate functional annotation help host cell human cell identify immune response IMPROVE Infectious disease mechanism mechanisms Organoid performed platform profile Protein protein expression provided Quantitative data regulate Regulatory Research resource RNA RNA-seq dataset severity splicing tissues transcriptional virus [DOI] 10.1186/s12967-022-03699-8 PMC 바로가기
COVID-19 Pathology in the Lung, Kidney, Heart and Brain: The Different Roles of T-Cells, Macrophages, and MicrothrombosisArticle Published on 2022-10-042022-11-15 Journal: Cells [Category] COVID19(2023년), SARS, 진단, [키워드] activated activated macrophages Activation age antibody Autopsy B-lymphocytes Brain change characteristic Clinical course controls COVID-19 COVID-19 case COVID-19 pathology elderly exhibited feature foci greater heart hearts highest Hyperactivation Inflammation Inflammatory kidney kidneys lung lung; Lymphocytes microglial Microthrombosis neuropathology. nine other tissue pathology pathophysiology PCR Platelets predominant role SARS-CoV-2 significantly significantly higher T-lymphocyte T-lymphocytes the disease tissue tissues viral antigens viral replication Viral RNA were used [DOI] 10.3390/cells11193124 PMC 바로가기
Computational exploration of the dual role of the phytochemical fortunellin: Antiviral activities against SARS-CoV-2 and immunomodulatory abilities against the hostArticle Published on 2022-10-012022-11-15 Journal: Computers in biology and medicine [Category] COVID19(2023년), SARS, 유전자 메커니즘, 치료제, [키워드] activity acute respiratory syndrome analyses Analysis Antiviral antiviral activity apoptosis pathway approach bind binding site Colon coronavirus disease Coronavirus-2 COVID-19 COVID-19 patients effective endoribonuclease enrichment enrichment analysis evaluate Fortunellin generate Genetic growth Host identify immunomodulation immunomodulatory immunomodulatory capability Infection inherent inhibiting Invasion liver lung cell majority mechanism MM-GBSA analysis molecular molecular docking molecular dynamics Molecular dynamics simulation Multi-target mutability network network pharmacology NHBE Ontology Organoid pancreatic pathway per day pro-inflammatory cytokine protective immunity protein-protein interaction SARS-CoV-2 SARS-CoV-2. Support target target proteins targets the SARS-CoV-2 therapeutic tissue damage tissues treating COVID-19 viral replication virion virus [DOI] 10.1016/j.compbiomed.2022.106049 PMC 바로가기
Biomarkers extracted by fully automated body composition analysis from chest CT correlate with SARS-CoV-2 outcome severityArticle Published on 2022-09-302022-11-15 Journal: Scientific Reports [Category] SARS, 바이오마커, [키워드] 95% CI adipose adjusted analysis Analysis analyzed approach association automated Biomarker body composition Chest Chest CT complex Computed tomography contribute Course death Deceased defined disease disease severity Endpoint endpoints feature female Female patients genders Infection investigated laboratory parameter male Mann-Whitney-U test marker Mortality Multiple multivariate logistic regression outcome Patient patients promoted remained risk risk stratification SARS-CoV-2 SARS-CoV-2 patients severe SARS-CoV-2 severity small patient cohort statistical significance tissue tissues two-sided Volume [DOI] 10.1038/s41598-022-20419-w PMC 바로가기
A Study on the Nature of SARS-CoV-2 Using the Shell Disorder Models: Reproducibility, Evolution, Spread, and AttenuationArticle Published on 2022-09-232022-11-16 Journal: Biomolecules [Category] SARS, 변종, [키워드] applied attenuation bat-CoV contagiousness coronavirus Coronaviruses correlated CoV COVID COVID-19 demonstrated disorder enzyme greater Hard immune system implication intrinsic Long COVID lung membrane protein Nature nucleocapsid protein nucleoprotein observation omicron pangolin Particle PID predicted PROTECT Replication Saliva SARS-CoV-2 shell supported tissues transmissions variant Viral load virion virulence virulence. virus [DOI] 10.3390/biom12101353 PMC 바로가기
Proteomic insights into SARS-CoV-2 infection mechanisms, diagnosis, therapies and prognostic monitoring methodsArticle Published on 2022-09-202022-11-16 Journal: Frontiers in Immunology [Category] SARS, 유전자 메커니즘, [키워드] acute respiratory syndrome body fluid caused Cell changes in coronavirus COVID-19 COVID-19 pandemic COVID-19 patients damaged Diagnosis Factor Host host infection Infection information Invasion marker mechanism mechanisms organism pathological change Perspective prognostic Protein protein biomarker proteomic study proteomics public health Quantitative SARS-CoV-2 SARS-COV-2 infection therapy tissues viral particle virus infection virus infection. [DOI] 10.3389/fimmu.2022.923387 PMC 바로가기
Tissue-specific pathway activities: A retrospective analysis in COVID-19 patientsArticle Published on 2022-09-152022-11-16 Journal: Frontiers in Immunology [Category] SARS, 치료기술, [키워드] ACE2 receptor activity Affect affected Alter anticoagulation arachidonic acid calculated changed changes in cholesterol Coagulation complement COVID-19 COVID-19 patient COVID-19 patients example expressed highlight Inflammation less linolenic acid lung Map mapped mechanism metabolism molecular multiple tissues non-COVID-19 patient organ other tissue pathway pathway activity Pathways progression Protein proteomics data RAS regulatory pathway reported Retrospective analysis SARS-CoV-2 SARS-COV-2 infection spleen the disease thrombosis Thyroid tissue tissue-specific proteomics data. tissues virus WikiPathways Wilcoxon test [DOI] 10.3389/fimmu.2022.963357 PMC 바로가기